Journal article
Inference about causation from examination of familial confounding (ICE FALCON): a model for assessing causation analogous to Mendelian randomization
Shuai Li, Minh Bui, John L Hopper
International Journal of Epidemiology | OXFORD UNIV PRESS | Published : 2020
DOI: 10.1093/ije/dyaa065
Abstract
BACKGROUND: We developed a method to make Inference about Causation from Examination of FAmiliaL CONfounding (ICE FALCON) using observational data for related individuals and considering changes in a pair of regression coefficients. ICE FALCON has some similarities to Mendelian randomization (MR) but uses in effect all the familial determinants of the exposure, not just those captured by measured genetic variants, and does not require genetic data nor make strong assumptions. ICE FALCON can assess tracking of a measure over time, an issue often difficult to assess using MR due to lack of a valid instrumental variable. METHODS: We describe ICE FALCON and present two empirical applications wit..
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Grants
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by National Breast Cancer Foundation
Awarded by Victorian Cancer Agency
Awarded by NHMRC Program grant
Funding Acknowledgements
The Australian Mammographic Density Twins and Sisters Study (AMDTSS) was supported by the National Health and Medical Research Council (NHMRC, grant numbers 1050561 and 1079102), Cancer Australia and National Breast Cancer Foundation (grant number 509307). S.L. is a Victorian Cancer Agency Early Career Research Fellow (grant number ECRF19020). J.L.H. is a NHMRC Senior Principal Research Fellow. The work was supported by the NHMRC Program grant (grant number 1074383).