Journal article

Hepatitis B and D in the Pacific Islands of Kiribati

Kathy Jackson, Rosemary Tekoaua, Thomas Holgate, Ros Edwards, Lilly Yuen, Alice Lee, Suellen Nicholson, Margaret Littlejohn, Stephen Locarnini, Kabiri Tuneti

Journal of Clinical Virology | ELSEVIER | Published : 2020

Abstract

BACKGROUND: Historical reports indicate that hepatitis B and hepatitis D are highly endemic in the Pacific Island of Kiribati but current levels are unknown. OBJECTIVES: To determine current prevalence of HBV and HDV in Kiribati, characterize the strains in both mono-infection and co-infection and assess individuals for antiviral therapy. STUDY DESIGN: Sera obtained from 219 patients were screened for HBsAg, HBeAg, HBV DNA, anti-HD, and HDV RNA. 61 HBV isolates were sequenced for genotype, phylogenetic analysis and detection of pre-core and basal core promoter mutations. 82 HDV isolates were also sequenced. RESULTS: 55.7 % HBsAg positive samples had antibodies to HDV and 73.2 % had detectabl..

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