Journal article

Early mobilisation post-stroke: a systematic review and meta-analysis of individual participant data

Venesha Rethnam, Peter Langhorne, Leonid Churilov, Kathryn S Hayward, Fanny Herisson, Simone R Poletto, Yanna Tong, Julie Bernhardt

DISABILITY AND REHABILITATION | TAYLOR & FRANCIS LTD | Published : 2020

Abstract

PURPOSE: To investigate the safety and efficacy of early mobilisation (EM) compared to usual care by meta-analysing individual participant data (IPD). MATERIALS AND METHODS: IPD were sought from randomised controlled trials comparing out-of-bed mobilisation starting within 48 h from stroke onset to usual care for acute stroke patients. Six trials were sourced from a recent Cochrane review. Favourable outcome (modified Rankin Scale 0-2) and death at 3 months post-stroke were compared between both groups using mixed-effect logistic regression modelling. Adjusted odds ratios (aORs) with respective 95% confidence intervals (95%CI) were reported. RESULTS: Out of 2630 participants, 1437 (54.6%) we..

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