Journal article

Prevalence of mutations associated with resistance to macrolides and fluoroquinolones in Mycoplasma genitalium: a systematic review and meta-analysis

Dorothy A Machalek, Yusha Tao, Hannah Shilling, Jorgen S Jensen, Magnus Unemo, Gerald Murray, Eric PF Chow, Nicola Low, Suzanne M Garland, Lenka A Vodstrcil, Christopher K Fairley, Jane S Hocking, Lei Zhang, Catriona S Bradshaw

LANCET INFECTIOUS DISEASES | ELSEVIER SCI LTD | Published : 2020

Abstract

BACKGROUND: Mycoplasma genitalium is now recognised as an important bacterial sexually transmitted infection. We summarised data from studies of mutations associated with macrolide and fluoroquinolone resistance in M genitalium to establish the prevalence of resistance. We also investigated temporal trends in resistance and aimed to establish the association between resistance and geographical location. METHODS: In this systematic review and meta-analysis, we searched PubMed, Embase, and MEDLINE for studies that included data for the prevalence of mutations associated with macrolide and fluoroquinolone resistance in M genitalium published in any language up to Jan 7, 2019. We defined prevale..

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