Sulfonated RAFT Copolymers as Heparin Mimetics: Synthesis, Reactivity Ratios, and Anticoagulant Activity
Abdullah Al Nahain, Vera Ignjatovic, Paul Monagle, John Tsanaktsidis, George Vamvounis, Vito Ferro
MACROMOLECULAR BIOSCIENCE | WILEY-V C H VERLAG GMBH | Published : 2020
The glycosaminoglycan heparin is a clinically important anticoagulant drug, primarily used to reduce the risk of blood clots (thrombosis) during surgery. Despite its importance in medicine and its continuous use over many decades, heparin suffers from several limitations associated with its heterogeneity and its extraction from animal tissues. In order to address these limitations, reversible addition-fragmentation chain transfer polymerization is utilized to prepare a library of heparin mimetic copolymers from the sulfonated monomers sodium 4-styrene sulfonate, potassium-3-sulfopropyl acrylate, potassium-3-sulfopropyl methacrylate, and sodium-2-acrylamido-2-methyl-1-propane sulfonate. Copol..View full abstract
Awarded by Australian Research Council
The authors gratefully acknowledge support from the Australian Research Council (DP170104431 to VF), University of Queensland (IPRS/UQCent PhD Scholarship to AAN), and CSIRO Manufacturing. This work was performed in part at the Queensland node of the Australian National Fabrication Facility, a company established under the National Collaborative Research Infrastructure Strategy to provide nano and microfabrication facilities for Australia's researchers. The authors thank Prof. Ezio Rizzardo, Drs Greg Coia, Craig Francis (CSIRO), Profs. Kris Thurecht, and Lisbeth Grondahl (UQ) for useful discussions. The authors also thank Chantal Attard and Vicky Karlaftis (Haematology Research, MCRI) for technical assistance.