Performance of immune-based and microbiological tests in children with tuberculosis meningitis in Europe: a multicentre Paediatric Tuberculosis Network European Trials Group (ptbnet) study
Robindra Basu Roy, Stephanie Thee, Daniel Blazquez-Gamero, Lola Falcon-Neyra, Olaf Neth, Antoni Noguera-Julian, Cristina Lillo, Luisa Galli, Elisabetta Venturini, Danilo Buonsenso, Florian Gotzinger, Nuria Martinez-Alier, Svetlana Velizarova, Folke Brinkmann, Steven B Welch, Maria Tsolia, Begona Santiago-Garcia, Renate Kruger, Marc Tebruegge
European Respiratory Journal | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2020
INTRODUCTION: Tuberculous meningitis (TBM) is often diagnostically challenging. Only limited data exist on the performance of interferon-γ release assays (IGRA) and molecular assays in children with TBM in routine clinical practice, particularly in the European setting. METHODS: Multicentre, retrospective study involving 27 healthcare institutions providing care for children with tuberculosis (TB) in nine European countries. RESULTS: Of 118 children included, 54 (45.8%) had definite, 38 (32.2%) probable and 26 (22.0%) possible TBM; 39 (33.1%) had TBM grade 1, 68 (57.6%) grade 2 and 11 (9.3%) grade 3. Of 108 patients who underwent cranial imaging 90 (83.3%) had at least one abnormal finding c..View full abstract
Awarded by European Union (FEDER)
Awarded by "Subvencions per a la Intensificacio de Facultatius Especialistes" (Departament de Salut de la Generalitat de Catalunya, Programa PERIS 2016-2020)
This project was carried out without dedicated funding. ptbnet is supported by the Deutsche Gesellschaft fur Internationale Zusammenarbeit. M. Tebruegge was supported by a Clinical Lectureship provided by the UK National Institute for Health Research (NIHR), and by a grant from the Technology Strategy Board/Innovate UK. B. Santiago-Garcia is funded by Spanish Ministry of Health - Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union (FEDER) (Contrato Juan Rodes, grant JR16/00036). R. Basu Roy is funded by an NIHR Academic Clinical Lectureship at the London School of Hygiene and Tropical Medicine. A. Noguera-Julian was supported by "Subvencions per a la Intensificacio de Facultatius Especialistes" (Departament de Salut de la Generalitat de Catalunya, Programa PERIS 2016-2020) (SLT008/18/00193). Funding information for this article has been deposited with the Crossref Funder Registry.