Journal article

Human milk oligosaccharide profiles and allergic disease up to 18 years

Caroline J Lodge, Adrian J Lowe, Elasma Milanzi, Gayan Bowatte, Michael J Abramson, Helen Tsimiklis, Christine Axelrad, Bianca Robertson, Aaron E Darling, Cecilie Svanes, Matthias Wjst, Shyamali C Dharmage, Lars Bode

Journal of Allergy and Clinical Immunology | MOSBY-ELSEVIER | Published : 2021


BACKGROUND: Human milk oligosaccharides (HMO) are a diverse range of sugars secreted in breast milk that have direct and indirect effects on immunity. The profiles of HMOs produced differ between mothers. OBJECTIVE: We sought to determine the relationship between maternal HMO profiles and offspring allergic diseases up to age 18 years. METHODS: Colostrum and early lactation milk samples were collected from 285 mothers enrolled in a high-allergy-risk birth cohort, the Melbourne Atopy Cohort Study. Nineteen HMOs were measured. Profiles/patterns of maternal HMOs were determined using LCA. Details of allergic disease outcomes including sensitization, wheeze, asthma, and eczema were collected at ..

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Funding Acknowledgements

This work was funded by the Asthma Australia and the National Health and Medical Research Council of Australia. None of the work was directed by or influenced by these institutions.