Journal article

Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution

Roxane M Pommier, Amelien Sanlaville, Laurie Tonon, Janice Kielbassa, Emilie Thomas, Anthony Ferrari, Anne-Sophie Sertier, Frederic Hollande, Pierre Martinez, Agnes Tissier, Anne-Pierre Morel, Maria Ouzounova, Alain Puisieux

NATURE COMMUNICATIONS | NATURE PUBLISHING GROUP | Published : 2020

Abstract

Claudin-low breast cancers are aggressive tumors defined by the low expression of key components of cellular junctions, associated with mesenchymal and stemness features. Although they are generally considered as the most primitive breast malignancies, their histogenesis remains elusive. Here we show that this molecular subtype of breast cancers exhibits a significant diversity, comprising three main subgroups that emerge from unique evolutionary processes. Genetic, gene methylation and gene expression analyses reveal that two of the subgroups relate, respectively, to luminal breast cancers and basal-like breast cancers through the activation of an EMT process over the course of tumor progre..

View full abstract

University of Melbourne Researchers

Grants

Awarded by Ligue Nationale contre le Cancer


Awarded by Cancer Research Centre of Lyon, France


Awarded by Victorian Comprehensive Cancer Centre of Melbourne, Australia


Funding Acknowledgements

We thank B. Manship for proofreading the manuscript. This work was supported by funding from the Ligue Nationale contre le Cancer (EL2016.LNCC/AIP and EL2019.LNCC/AIP) and SIRIC LYriCAN (INCa-DGOS-Inserm_12563). This work was additionally supported by funding from Inserm in the framework of the International Associated Laboratory between Cancer Research Centre of Lyon, France, and the Victorian Comprehensive Cancer Centre of Melbourne, Australia (Appel a projets LIA/LEA 2016, ASC17019CSA). This work was additionally supported by funding from Le Cancer du sein. Parlons-en! association.