Validation of the HAPPI Kids Continuous Age-Specific Pediatric Reference Intervals
Monsurul Hoq, Susan Matthews, Vicky Karlaftis, Janet Burgess, Susan Donath, John Carlin, Vera Ignjatovic, Paul Monagle
JOURNAL OF APPLIED LABORATORY MEDICINE | OXFORD UNIV PRESS INC | Published : 2020
INTRODUCTION: To facilitate best possible patient care, reference intervals (RIs) adopted by a laboratory must be appropriate for the population demographics and, where applicable, the analytical principle and/or the analytical instrument used. While guidelines from the Clinical and Laboratory Standard Institute (CLSI) recommend a validation process for discrete RIs, there are no current recommendations for the validation process for continuous RIs. This study aimed to validate recently published, HAPPI Kids continuous RIs, in a routine laboratory. METHODS: Initially, the difference in test results between the primary study laboratory that contributed to previous RIs development and a routin..View full abstract
This study was primarily funded by The Royal Children's Hospital Foundation, with supplementary research funding from Ortho Clinical Diagnostics. In addition, the study received in-kind reagent supply from Medical and Scientific Affairs at Roche Diagnostics International. M. Hoq, NHMRC Post Graduate Scholarship.