Validation of the HAPPI Kids Continuous Age-Specific Pediatric Reference Intervals

Abstract

Introduction: To facilitate best possible patient care, reference intervals (RIs) adopted by a laboratory must be appropriate for the population demographics and, where applicable, the analytical principle and/or the analytical instrument used. While guidelines from the Clinical and Laboratory Standard Institute (CLSI) recommend a validation process for discrete RIs, there are no current recommendations for the validation process for continuous RIs. This study aimed to validate recently published, HAPPI Kids continuous RIs, in a routine laboratory. Methods: Initially, the difference in test results between the primary study laboratory that contributed to previous RIs development and a routin..