Journal article

Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases

Maryam Rashidi, Ian P Wicks, James E Vince

Trends in Molecular Medicine | ELSEVIER SCI LTD | Published : 2020

Abstract

The accumulation of cellular and environmental microparticles has been linked to many diseases associated with tissue inflammation. These particulate-driven diseases include joint, lung, kidney, cardiovascular, and neurodegenerative disorders. Recently a conserved proinflammatory inflammasome signaling pathway elicited by such microparticles has become apparent. Here, we review disease-promoting microparticles and the mechanisms by which they trigger activation of the inflammasome complexes responsible for generating bioactive interleukin-1β (IL-1β) and inducing cell death. We highlight how microparticle-induced inflammasome and cell death responses diverge from canonical inflammasome activa..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by NHMRC Medical Research Future Fund Practitioner Fellowship


Awarded by Australian Government Independent Research Institute Infrastructure Support Scheme


Funding Acknowledgements

J.E.V. is supported by National Health and Medical Research Council of Australia Project Grants (1145788 and 1101405), an Ideas Grant (1183070). and Fellowship (1141466). M.R. is supported by a Mathison Centenary Fellowship, The University of Melbourne. I.P.W. is supported by the Reid Charitable Trusts, a Program Grant from the National Health and Medical Research Council (NHMRC) of Australia (1113577) and an NHMRC Medical Research Future Fund Practitioner Fellowship (1154325). This work was also supported by operational infrastructure grants through the Australian Government Independent Research Institute Infrastructure Support Scheme (9000220) and the Victorian State Government Operational Infrastructure Support, Australia.