Journal article

Sex effects across the lifespan in women with multiple sclerosis

Kristen M Krysko, Jennifer S Graves, Ruth Dobson, Ayse Altintas, Maria Pia Amato, Jacqueline Bernard, Simona Bonavita, Riley Bove, Paola Cavalla, Marinella Clerico, Teresa Corona, Anisha Doshi, Yara Fragoso, Dina Jacobs, Vilija Jokubaitis, Doriana Landi, Gloria Llamosa, Erin E Longbrake, Elisabeth Maillart, Monica Marta Show all

Therapeutic Advances in Neurological Disorders | SAGE PUBLICATIONS LTD | Published : 2020

Abstract

Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating central nervous system disorder that is more common in women, with onset often during reproductive years. The female:male sex ratio of MS rose in several regions over the last century, suggesting a possible sex by environmental interaction increasing MS risk in women. Since many with MS are in their childbearing years, family planning, including contraceptive and disease-modifying therapy (DMT) counselling, are important aspects of MS care in women. While some DMTs are likely harmful to the developing fetus, others can be used shortly before or until pregnancy is confirmed. Overall, pregnancy decreases risk of MS relapses, w..

View full abstract

Grants

Awarded by Sylvia Lawry Physician Fellowship through the National Multiple Sclerosis Society


Funding Acknowledgements

The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Kristen M. Krysko is funded by a Sylvia Lawry Physician Fellowship through the National Multiple Sclerosis Society [FP-1605-08753 (Krysko)].