Vascular calcification in skin and subcutaneous tissue in patients with chronic and end-stage kidney disease
Irene Ruderman, Tim D Hewitson, Edward R Smith, Stephen G Holt, Belinda Wigg, Nigel D Toussaint
BMC NEPHROLOGY | BMC | Published : 2020
BACKGROUND: Vascular calcification (VC) is well described in large- and medium-sized vessels in patients with chronic kidney disease (CKD), especially in those with end-stage kidney disease (ESKD) on dialysis. Medial calcification is particularly prevalent in this population and contributes to arterial stiffness and increased cardiovascular mortality and morbidity. Apart from in the setting of calciphylaxis, few studies have assessed skin and subcutaneous calcification and associations with abnormalities of bone and mineral metabolism in patients with CKD. METHODS: We performed a single-centre observational study to evaluate incisional skin tissue samples from three anatomical sites in patie..View full abstract
This work was kindly funded by an investigator-initiated research grant from The Royal Melbourne Hospital, Australia. Funding was used for purchase of consumable items for histopathology and RT-PCR investigation.