Osteosarcopenia: beyond age-related muscle and bone loss
Gabriela Fagundes Belchior, Ben Kirk, Evela Aparecida Pereira da Silva, Gustavo Duque
European Geriatric Medicine | SPRINGER | Published : 2020
PURPOSE: Osteosarcopenia is a geriatric syndrome characterized by declines in bone density and microarchitecture and muscle mass and strength, which has gained clinical interest due to its association with falls and fragility fractures. METHODS: This review discusses the epidemiology of osteosarcopenia including clinical assessment, the pathophysiological aspects leading to the loss of muscle and bone mass, and efficacious therapeutic strategies to combat this syndrome. RESULTS: The etiology of osteosarcopenia is thought to include genetic and environmental factors which interact with muscle and bone at the cellular level, reinforcing that these tissues are interconnected not only by mechani..View full abstract
The authors would like to thank the Australian Institute for Musculoskeletal Science (AIMSS) for providing support for this study.