Journal article

Osteosarcopenia: beyond age-related muscle and bone loss

Gabriela Fagundes Belchior, Ben Kirk, Evela Aparecida Pereira da Silva, Gustavo Duque

European Geriatric Medicine | SPRINGER | Published : 2020

Abstract

PURPOSE: Osteosarcopenia is a geriatric syndrome characterized by declines in bone density and microarchitecture and muscle mass and strength, which has gained clinical interest due to its association with falls and fragility fractures. METHODS: This review discusses the epidemiology of osteosarcopenia including clinical assessment, the pathophysiological aspects leading to the loss of muscle and bone mass, and efficacious therapeutic strategies to combat this syndrome. RESULTS: The etiology of osteosarcopenia is thought to include genetic and environmental factors which interact with muscle and bone at the cellular level, reinforcing that these tissues are interconnected not only by mechani..

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University of Melbourne Researchers

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Funding Acknowledgements

The authors would like to thank the Australian Institute for Musculoskeletal Science (AIMSS) for providing support for this study.