Journal article

Topology predicts long-term functional outcome in early psychosis.

Margot Fournier, Martina Scolamiero, Mehdi M Gholam-Rezaee, Martine Cleusix, Raoul Jenni, Carina Ferrari, Philippe Golay, Philipp S Baumann, Michel Cuenod, Philippe Conus, Kim Q Do, Kathryn Hess

Mol Psychiatry | Published : 2020

Abstract

Early intervention in psychosis is crucial to improving patient response to treatment and the functional deficits that critically affect their long-term quality of life. Stratification tools are needed to personalize functional deficit prevention strategies at an early stage. In the present study, we applied topological tools to analyze symptoms of early psychosis patients, and detected a clear stratification of the cohort into three groups. One of the groups had a significantly better psychosocial outcome than the others after a 3-year clinical follow-up. This group was characterized by a metabolic profile indicative of an activated antioxidant response, while that of the groups with poorer..

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Grants

Awarded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)