Journal article
NOTCH Your Usual Suspect: MYC Charged with Controlling Neuroendocrine Cell-Fate in Small Cell Lung Cancer
J Ng, KD Sutherland
Cancer Cell | CELL PRESS | Published : 2020
Abstract
Small cell lung cancer (SCLC) is highly heterogeneous. In this issue of Cancer Cell, Ireland et al. demonstrate that MYC mediates neuroendocrine cell plasticity in SCLC by activating NOTCH signaling. This MYC-NOTCH axis controls the dynamic behavior of tumor cells, resulting in the co-existence of SCLC subtypes within individual tumors.
Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
We are grateful to P. Maltezos and Biorender (https://biorender.com) for assistance with preparation of the Figure. This work was supported by the Australian National Health and Medical Research Council, Australia (Project Grant 1159955 to K.D.S.) and by the Peter and Julie Alston Centenary Fellowship. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.