Associations between grass pollen exposuresin uteroand in early life with food allergy in 12-month-old infants
Nugroho Harry Susanto, Adrian J Lowe, Agus Salim, Jennifer J Koplin, Mimi LK Tang, Noor HA Suaini, Anne-Louise Ponsonby, Katrina J Allen, Shyamali C Dharmage, Bircan Erbas
International Journal of Environmental Health Research | TAYLOR & FRANCIS LTD | Published : 2020
Birth during pollen seasons may influence food allergy risk but no study has assessed pollen exposure. Using the HealthNuts population-based cohort of 5276 infants, we assessed grass pollen exposures, in utero and up to the first 6 months of life, on hen's egg, sesame and peanut allergy outcomes at 12 months. Cumulative pollen exposure in the first 7 days of life increased risk of peanut sensitization aMOR (adjusted multinomial odds ratio) = 1.21 (95% CI: 1.01-1.44). Exposure between first 4-6 months of life increased risk of hen's egg aMOR = 1.02 (95% CI: 1.004-1.04) and sensitization to all foods aMOR = 1.02 (95% CI: 1.003-1.04). Grass pollen exposure was associated with food challenge dia..View full abstract
This work was supported by funding from the National Health & Medical Research Council (NHMRC) of Australia; Ilhan Food Allergy Foundation; AnaphylaxiStop; the Charles and Sylvia Viertel Medical Research Foundation; the Victorian Government's Operational Infrastructure Support Program; and the NHMRC Centre for Food and Allergy Research. K.J.A., A.J.L., J.J.K., and S.C.D. hold NHMRC awards.