Journal article

Site-Specific Epicardium-to-Endocardium Dissociation of Electrical Activation in a Swine Model of Atrial Fibrillation

Tomos E Walters, Geoffrey Lee, Adam Lee, Richard Sievers, Jonathan M Kalman, Edward P Gerstenfeld

JACC Clinical Electrophysiology | ELSEVIER | Published : 2020


OBJECTIVES: This study sought to define the extent and spatial distribution of endocardial-epicardial dissociation (EED) in a swine model. BACKGROUND: The mechanisms underlying persistent atrial fibrillation (AF) remain unclear. METHODS: Sixteen swine underwent simultaneous endocardial and epicardial mapping using 32-electrode grid catheters. This included 6 swine with rapid atrial pacing-induced atrial remodeling. Three right atrial (RA) and 3 left atrial (LA) regions were mapped during sinus rhythm, atrial pacing, acute or persistent AF, and AF in the presence of pericardial acetylcholine. Unipolar electrogram recordings over 10-s epochs underwent offline phase analysis using customized so..

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Funding Acknowledgements

Dr. Lee contributed equally to this work and are joint first authors. The NavX Velocity mapping system and multielectrode mapping catheters were provided for this study without charge by Abbott Inc. The neurostimulators and pacing leads used for device implantation were provided without charge by Medtronic Inc. The study was supported by the Todd Spieker fund. Dr. Gerstenfeld has received an investigator-initiated research grant from Abbott Inc. for the animals used in this study; and has received lecture honoraria from Medtronic, Inc. and Abbott. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.