Journal article

Metabolic and haemodynamic resting-state connectivity of the human brain: a high-temporal resolution simultaneous BOLD-fMRI and FDG-fPET multimodality study

Sharna Jamadar, Phillip GD Ward, Emma Xingwen Liang, Edwina Orchard, Zhaolin Chen, Gary Egan

Published : 2020

Abstract

Abstract Simultaneous FDG-PET/fMRI ([18F]-fluorodeoxyglucose positron emission tomography functional magnetic resonance imaging) provides the capacity to image two sources of energetic dynamics in the brain – glucose metabolism and haemodynamic response. Functional fMRI connectivity has been enormously useful for characterising interactions between distributed brain networks in humans. Metabolic connectivity based on static FDG-PET has been proposed as a biomarker for neurological disease; but static FDG-PET cannot be used to estimate subject-level measures of connectivity , only across-subject covariance . Here, we applied high-temporal resolution constant infusion functional PET (fPET) to ..

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University of Melbourne Researchers

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