Journal article
Paper-Based Acoustofluidics for Separating Particles and Cells
Jason Zhou, Ruhollah Habibi, Farzan Akbaridoust, Adrian Neild, Reza Nosrati
Analytical Chemistry | American Chemical Society | Published : 2020
Abstract
Paper is emerging as a versatile platform for automated fluid handling with a broad range of applications in medical diagnostics and analytical chemistry. However, selectively controlling analyte transport in paper to achieve concentration or selection has been a challenge for functional analysis. Here, by combining paper-based microfluidics with acoustics, we present a rapid and powerful method to size dependently control movement of microparticles and cells in paper using surface acoustic waves (SAW). We demonstrate the unique capability of the paper-based SAW approach to trap and concentrate microparticles in paper and release them when required, achieving collection efficiency of over 98..
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Awarded by Australian Research Council (ARC)
Funding Acknowledgements
This work was supported by the Australian Research Council (ARC) Discovery Project Grant (DP160101263) to A.N. and Monash Interdisciplinary Research Grants to R.N. This work was performed in part at the Melbourne Centre for Nanofabrication (MCN) in the Victorian Node of the Australian National Fabrication Facility (ANFF). We thank Jennifer Dyson, James Carthew, and Esma Dervisevic for supplying the human prostate cancer PC3 cells. We also thank Citsabehsan Devendran and Prasanna Nair for their help with experimental methods.