Journal article

Utility of genetic and non-genetic risk factors in predicting coronary heart disease in Singaporean Chinese

Xuling Chang, Agus Salim, Rajkumar Dorajoo, Yi Han, Chiea-Chuen Khor, Rob M van Dam, Jian-Min Yuan, Woon-Puay Koh, Jianjun Liu, Daniel YT Goh, Xu Wang, Yik-Ying Teo, Yechiel Friedlander, Chew-Kiat Heng

European Journal of Preventive Cardiology | SAGE PUBLICATIONS LTD | Published : 2017

Abstract

Background Although numerous phenotype based equations for predicting risk of 'hard' coronary heart disease are available, data on the utility of genetic information for such risk prediction is lacking in Chinese populations. Design Case-control study nested within the Singapore Chinese Health Study. Methods A total of 1306 subjects comprising 836 men (267 incident cases and 569 controls) and 470 women (128 incident cases and 342 controls) were included. A Genetic Risk Score comprising 156 single nucleotide polymorphisms that have been robustly associated with coronary heart disease or its risk factors ( p < 5 × 10-8) in at least two independent cohorts of genome-wide association studies was..

View full abstract

Grants

Awarded by HUJ-CREATE Programme of the National Research Foundation, Singapore


Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by National Institute of Health, USA


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002) and Australian National Health and Medical Research Council (NHMRC) Grant No. 1108967. The Singapore Chinese Health Study (SCHS) cohort was funded by National Institute of Health, USA (grant no. R01 CA144034 and UM1 CA182876). Xuling Chang is supported by a Graduate Research Scholarship from the National University of Singapore.