Journal article

C-reactive protein and serum creatinine, but not haemoglobin A1c, are independent predictors of coronary heart disease risk in non-diabetic Chinese

Agus Salim, E Shyong Tai, Vincent Y Tan, Alan H Welsh, Reginald Liew, Nasheen Naidoo, Yi Wu, Jian-Min Yuan, Woon P Koh, Rob M van Dam

European Journal of Preventive Cardiology | SAGE PUBLICATIONS LTD | Published : 2016

Abstract

In western populations, high-sensitivity C-reactive protein (hsCRP), and to a lesser degree serum creatinine and haemoglobin A1c, predict risk of coronary heart disease (CHD). However, data on Asian populations that are increasingly affected by CHD are sparse and it is not clear whether these biomarkers can be used to improve CHD risk classification.We conducted a nested case-control study within the Singapore Chinese Health Study cohort, with incident 'hard' CHD (myocardial infarction or CHD death) as an outcome. We used data from 965 men (298 cases, 667 controls) and 528 women (143 cases, 385 controls) to examine the utility of hsCRP, serum creatinine and haemoglobin A1c in improving the p..

View full abstract

Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Singapore National Medical Research Council


Awarded by National Institute of Health, USA


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Australian National Health and Medical Research Council (grant no. 1108967) and Singapore National Medical Research Council (grant no. 1270/2010). The Singapore Chinese Health Study (SCHS) cohort was funded by National Institute of Health, USA (grant no. NCI RO1 CA055069, R35 CA053890, R01 CA080205, R01 CA098497 and R01 CA144034).