Journal article

Breast cancer risk assessment using genetic variants and risk factors in a Singapore Chinese population

Charmaine Pei Ling Lee, Astrid Irwanto, Agus Salim, Jian-min Yuan, Jianjun Liu, Woon Puay Koh, Mikael Hartman

Breast Cancer Research | BMC | Published : 2014


INTRODUCTION:Genetic variants for breast cancer risk identified in genome-wide association studies (GWAS) in Western populations require further testing in Asian populations. A risk assessment model incorporating both validated genetic variants and established risk factors may improve its performance in risk prediction of Asian women. METHODS:A nested case-control study of female breast cancer (411 cases and 1,212 controls) within the Singapore Chinese Health Study was conducted to investigate the effects of 51 genetic variants identified in previous GWAS on breast cancer risk. The independent effect of these genetic variants was assessed by creating a summed genetic risk score (GRS) after a..

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Awarded by National Cancer Institute, Bethesda, Maryland, USA


Funding Acknowledgements

We thank Siew-Hong Low of the National University of Singapore for supervising the field work of the Singapore Chinese Health Study, and Kazuko Arakawa and Renwei Wang for the development and management of the cohort study database. We also thank the Singapore Cancer Registry in Singapore for assistance with the identification of cancer cases via database linkages. Finally, we acknowledge the founding principal investigator of the Singapore Chinese Health Study - Mimi C. Yu. The Singapore Chinese Health Study was supported by grants R01 CA55069, R35 CA53890, R01 CA80205, and R01 CA144034 from the National Cancer Institute, Bethesda, Maryland, USA. CPLL was supported by the NUS Graduate School for Integrative Sciences and Engineering (NGS) Scholarship. AI was supported by the A*STAR Singapore International Graduate Award (SINGA).