Diagnosis of Diabetes Mellitus Using HbA1c in Asians: Relationship Between HbA1c and Retinopathy in a Multiethnic Asian Population
Charumathi Sabanayagam, Eric YH Khoo, Weng Kit Lye, M Kamran Ikram, Ecosse L Lamoureux, Ching Yu Cheng, Maudrene LS Tan, Agus Salim, Jeannette Lee, Su-Chi Lim, Subramaniam Tavintharan, Ah-Chuan Thai, Derrick Heng, Stefan Ma, E Shyong Tai, Tien Y Wong
The Journal of Clinical Endocrinology & Metabolism | ENDOCRINE SOC | Published : 2015
CONTEXT: Hemoglobin A1c (HbA1c) ≥ 6.5% (47.5 mmol/mol) has recently been included as a criterion for the diagnosis of diabetes mellitus. It is unclear whether this criterion is appropriate in Asians. OBJECTIVE: To examine the relationship between HbA1c and diabetes-specific moderate retinopathy in Asian ethnic groups. DESIGN, SETTING, AND PARTICIPANTS: Four independent population-based cross-sectional studies (2004-2011) in Singapore representing the three major Asian ethnic groups (n = 13 170 adults aged ≥ 25 y: Chinese, 5834; Malays, 3596; and Indians, 3740). MAIN OUTCOME: Moderate retinopathy was assessed from digital retinal photographs and defined as a level >43 using the Early Treatmen..View full abstract
Awarded by National Medical Research Council
Awarded by Biomedical Research Council
Awarded by Biomedical Research Council, Singapore
The SEED study was supported by National Medical Research Council Grants 0796/2003, 0863/2004, and CSI/0002/2005, and Biomedical Research Council Grant 501/1/25-5. The SP2 study was supported by grants from the National Medical Research Council (Grants 0838/2004, 0863/2004, and IRG07nov013) and the Biomedical Research Council (Grants 03/1/27/18/216 and 08/1/35/19/550), Singapore.