Association of ADIPOQ gene with obesity and adiponectin levels in Malaysian Malays
Yamunah Devi Apalasamy, Sanjay Rampal, Agus Salim, Foong Ming Moy, Awang Bulgiba, Zahurin Mohamed
Molecular Biology Reports | SPRINGER | Published : 2014
Studies have shown that single-nucleotide polymorphisms (SNPs) on the ADIPOQ gene have been linked with obesity and with adiponectin levels in various populations. Here, we aimed to investigate the association of ADIPOQ rs17366568 and rs3774261 SNPs with obesity and with adiponectin levels in Malaysian Malays. Obesity parameters and adiponectin levels were measured in 574 subjects. Genotyping was performed using real-time polymerase chain reaction and Sequenom MassARRAY. A significant genotypic association was observed between ADIPOQ rs17366568 and obesity. The frequencies of AG and AA genotypes were significantly higher in the obese group (11%) than in the non-obese group (5%) (P=0.024). Th..View full abstract
Awarded by University of Malaya
Awarded by HIR-MOHE
This study was supported by research grants RG075-09HTM from the University of Malaya and HIR-MOHE E000049-20001. We would like to acknowledge the assistance of Ms. Devi Peramalah, the Wellness Program team, Narong Jaturas, Thanet Sornda, the medical students who assisted in data collection, and all of the participants in this research. We would also like to acknowledge Barbara Every, a board-certified Editor in the Life Sciences (ELS) for editing the manuscript.