Susceptibility and Gene Interaction Study of the Angiotensin II Type 1 Receptor (AGTR1) Gene Polymorphisms with Non-Alcoholic Fatty Liver Disease in a Multi-Ethnic Population
Shamsul Mohd Zain, Zahurin Mohamed, Sanjiv Mahadeva, Sanjay Rampal, Roma Choudhury Basu, Phaik-Leng Cheah, Agus Salim, Rosmawati Mohamed
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2013
Angiotensin II type 1 receptor (AGTR1) has been reported to play a fibrogenic role in non-alcoholic fatty liver disease (NAFLD). In this study, five variants of the AGTR1 gene (rs3772622, rs3772627, rs3772630, rs3772633, and rs2276736) were examined for their association with susceptibility to NAFLD. Subjects made up of 144 biopsy-proven NAFLD patients and 198 controls were genotyped using TaqMan assays. The liver biopsy specimens were histologically graded and scored according to the method of Brunt. Single locus analysis in pooled subjects revealed no association between each of the five variants with susceptibility to NAFLD. In the Indian ethnic group, the rs2276736, rs3772630 and rs37726..View full abstract
Awarded by University Malaya Research
Awarded by High Impact Research Ministry of Higher Education (HIRMOHE)
This study was supported by University Malaya Research Grant RG069/09HTM and RG364/11HTM, and by the High Impact Research Ministry of Higher Education (HIRMOHE) Grant E000025-20001. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.