Journal article

KCNQ1 SNPS and susceptibility to diabetic nephropathy in East Asians with type 2 diabetes

XL Lim, S Nurbaya, A Salim, ES Tai, S Maeda, Y Nakamura, DPK Ng

DIABETOLOGIA | SPRINGER | Published : 2012

Abstract

AIMS/HYPOTHESIS: A Japanese study had earlier reported that KCNQ1 single-nucleotide polymorphisms (SNPs) may be associated with diabetic nephropathy. To further investigate this finding, we analysed three SNPs, rs2237895, rs2237897 and rs2283228, within the KCNQ1 locus for association with albuminuria among Chinese type 2 diabetic patients residing in Singapore. Albuminuria was analysed as both categorical (micro- and macroalbuminuria) and continuous traits (log(e) albumin/creatinine ratio [ACR]). METHODS: A total of 752 Chinese patients with type 2 diabetes were included in the study. Albuminuria was determined by ACR using spot urine samples, and renal function was approximated using estim..

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