Journal article

Diabetes with Hypertension as Risk Factors for Adult Dengue Hemorrhagic Fever in a Predominantly Dengue Serotype 2 Epidemic: A Case Control Study

Junxiong Pang, Agus Salim, Vernon J Lee, Martin L Hibberd, Kee Seng Chia, Yee Sin Leo, David C Lye

PLoS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2012


BACKGROUND: Dengue hemorrhagic fever (DHF) is a severe form of dengue, characterized by bleeding and plasma leakage. A number of DHF risk factors had been suggested. However, these risk factors may not be generalized to all populations and epidemics for screening and clinical management of patients at risk of developing DHF. This study explored demographic and comorbidity risk factors for DHF in adult dengue epidemics in Singapore in year 2006 (predominantly serotype 1) and in year 2007-2008 (predominantly serotype 2). METHODS: A retrospective case-control study was conducted with 149 DHF and 326 dengue fever (DF) patients from year 2006, and 669 DHF and 1,141 DF patients from year 2007-2008..

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Awarded by National Medical Research Council

Funding Acknowledgements

This work was supported by the National Medical Research Council grant NMRC/TCR/005/2008. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.The authors have read the journal's policy and have the following conflicts: VJL has received unrelated research funding from GlaxoSmithKline; YSL is a consultant to Sanofi-Pasteur.