Can body fat distribution, adiponectin levels and inflammation explain differences in insulin resistance between ethnic Chinese, Malays and Asian Indians?
H Gao, A Salim, J Lee, ES Tai, RM van Dam
International Journal of Obesity | NATURE PUBLISHING GROUP | Published : 2012
OBJECTIVE: Diabetes in Asia constitutes approximately half of the global burden. Although insulin resistance and incidence of type 2 diabetes differ substantially between ethnic groups within Asia, the reasons for these differences are poorly understood. We evaluated to what extent body fatness, adiponectin levels and inflammation mediate the relationship between ethnicity and insulin resistance in an Asian setting. DESIGN: Cross-sectional population-based study. SUBJECTS: In total, 4136 adult Chinese, Malays and Asian Indians residing in Singapore. MEASUREMENTS: Insulin resistance was assessed using homeostasis model assessment (HOMA-IR) and systemic inflammation by C-reactive protein (CRP)..View full abstract
Awarded by Biomedical Research Council
Awarded by National Medical Research Council
This study was supported by the Biomedical Research Council (Grant number 03/1/27/18/216) and the National Medical Research Council (Grant numbers 0838/2004 and NMRC/CSI/0002/2005).