Journal article

Muscle strength and gait speed rather than lean mass are better indicators for poor cognitive function in older men

Sophia X Sui, Kara L Holloway-Kew, Natalie K Hyde, Lana J Williams, Sarah Leach, Julie A Pasco



We aimed to examine muscle strength, function and mass in relation to cognition in older men. This cross-sectional data-set included 292 men aged ≥60 yr. Handgrip strength (kg) was measured by dynamometry, gait speed by 4-metre walk (m/s) and appendicular lean mass (kg) by dual-energy x-ray absorptiometry. Cognition was assessed across four domains: psychomotor function, attention, visual learning and working memory. Composite scores for overall cognition were calculated. Bivariate analyses indicated that handgrip strength and gait speed were positively associated with cognitive function. After accounting for confounders, positive associations between individual muscle (or physical) measures..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council (NHMRC) Australia

Awarded by NHMRC

Funding Acknowledgements

The authors acknowledge the men who participated in the study, and the staff who contributed to the data collection. The Geelong Osteoporosis Study was funded by the National Health and Medical Research Council (NHMRC) Australia (projects 251638, 628582). SXS was supported by a Deakin Postgraduate Scholarship in conjunction with Geelong Medical and Hospital Benefits Association (GMHBA); KLH-K by an Alfred Deakin Postdoctoral Research Fellowship; NKH by a Dean's Research Postdoctoral Fellowship (Deakin University) and LJW by a NHMRC Career Development Fellowship (1064272) and a NHMRC Investigator grant (1174060). The funding organisations played no role in the design or conduct of the study, in the collection, management, analysis and interpretation of the data, nor in the preparation, review and approval of the manuscript. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committees and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Human Research Ethics Committee at Barwon Health.