Journal article

A taxonomy of seizure dynamotypes

Maria Luisa Saggio, Dakota Crisp, Jared M Scott, Philippa Karoly, Levin Kuhlmann, Mitsuyoshi Nakatani, Tomohiko Murai, Matthias Duempelmann, Andreas Schulze-Bonhage, Akio Ikeda, Mark Cook, Stephen Gliske, Jack Lin, Christophe Bernard, Viktor Jirsa, William C Stacey

eLife | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2020

Abstract

Seizures are a disruption of normal brain activity present across a vast range of species and conditions. We introduce an organizing principle that leads to the first objective Taxonomy of Seizure Dynamics (TSD) based on bifurcation theory. The 'dynamotype' of a seizure is the dynamic composition that defines its observable characteristics, including how it starts, evolves and ends. Analyzing over 2000 focal-onset seizures from multiple centers, we find evidence of all 16 dynamotypes predicted in TSD. We demonstrate that patients' dynamotypes evolve during their lifetime and display complex but systematic variations including hierarchy (certain types are more common), non-bijectivity (a pati..

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Grants

Awarded by European Union


Awarded by DFG/Cluster of Excellence BrainLinks-BrainTools


Awarded by Ministry of Education, Culture, Sports, Science and Technology


Awarded by National Health and Medical Research Council


Awarded by Horizon 2020 Framework Programme


Awarded by Horizon 2020 m-Gate project Marie Sklodowska-Curie grant


Awarded by Fondation pour la Recherche Medicale


Awarded by National Institutes of Health


Funding Acknowledgements

European Union Seventh Framework Programme 211713 Matthias Dumpelmann Andreas Schulze-BonhageDFG/Cluster of Excellence BrainLinks-BrainTools 1086 Matthias Dumpelmann Andreas Schulze-BonhageMinistry of Education, Culture, Sports, Science and Technology 15H05871 Tomohiko Murai Akio IkedaMinistry of Education, Culture, Sports, Science and Technology 19H03574 Tomohiko Murai Akio IkedaNational Health and Medical Research Council GNT1183119 Mark Cook Levin KuhlmannLigue Francaise contre l'Epilepsie Maria Luisa SaggioHorizon 2020 Framework Programme 785907 Viktor JirsaHorizon 2020 Framework Programme 945539 Viktor JirsaHorizon 2020 m-Gate project Marie Sklodowska-Curie grant agreement no. 765549 Mitsuyoshi NakataniFondation pour la Recherche Medicale DIC 20161236442 Christophe Bernard Viktor JirsaSATT Sud Est The Virtual Brain Christophe Bernard Viktor JirsaAgence Nationale de la Recherche EPINOV Viktor JirsaNational Institutes of Health K01-ES026839 Stephen V GliskeNational Institutes of Health K08-NS069783 Stephen V Gliske William C StaceyNational Institutes of Health R01-NS094399 Dakota Crisp Jared M Scott Stephen V Gliske Jack Lin William C StaceyMichigan Medicine Robbins Family Research Fund Dakota Crisp William C StaceyMichigan Medicine Lucas Family Research Fund Dakota Crisp William C Stacey