Journal article

Acute NMDA Receptor Antagonism Impairs Working Memory Performance but Not Attention in Rats-Implications for the NMDAr Hypofunction Theory of Schizophrenia

Jaime Lee, Maarten van den Buuse, Jess Nithianantharajah, Nigel C Jones

Behavioral Neuroscience | AMER PSYCHOLOGICAL ASSOC | Published : 2020

Abstract

Cognitive deficits in schizophrenia, which include impairments in working memory and attention, represent some of the most disabling symptoms of this complex psychiatric condition, and lack effective treatments. NMDA receptor (NMDAr) hypofunction is a strong candidate mechanism underlying schizophrenia pathophysiology, and has been modeled preclinically using acute administration of NMDAr antagonists to rodents to investigate biological mechanisms underpinning cognitive dysfunction. However, whether and how NMDAr hypofunction specifically influences all affected cognitive domains is unclear. Here we studied the effects of the NMDAr antagonist MK-801 (dizocilpine) on tasks of attention and wo..

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Grants

Funding Acknowledgements

This work was supported by Australian Research Council Future Fellowships (Nigel C. Jones and Jess Nithianantharajah), and an National Health and Medical Research Council of Australia project grant (Nigel C. Jones). Jaime Lee was supported by an Australian Postgraduate Award scholarship through the University of Melbourne.