Journal article

High Prudent diet factor score predicts lower relapse hazard in early multiple sclerosis

Steve Simpson-Yap, Wendy H Oddy, Bruce Taylor, Robyn M Lucas, Lucinda J Black, Anne-Louise Ponsonby, Leigh Blizzard, Ingrid van der Mei

Multiple Sclerosis Journal | SAGE PUBLICATIONS LTD | Published : 2020

Abstract

Background: Dietary patterns and their association with subsequent clinical course have not been well studied in early multiple sclerosis (MS). Objectives: To describe dietary patterns in people in 5 years following first clinical demyelination and assess associations with MS conversion and relapse. Methods: This study included baseline food frequency questionnaire dietary intake (entry to the Ausimmune Study) and 5-year follow-up; iterated principal factor analysis was applied. MS conversion and relapse risks were assessed by Cox proportional hazards models, adjusted for age, sex, study site, education, body mass index (BMI), smoking and omega-3 supplement use. Results: In cases with a firs..

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Grants

Awarded by National Multiple Sclerosis Society of the United States of America


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: The Ausimmune and AusLong Studies were funded by the National Multiple Sclerosis Society of the United States of America (award RG3364A1/2) and the National Health and Medical Research Council of Australia (APP316901 and 224215). L.JB. is supported by an MS Research Australia Postdoctoral Fellowship and a Curtin University Research Fellowship.