Journal article

A Genomic Test for Colorectal Cancer Risk: Is This Acceptable and Feasible in Primary Care?

Sibel Saya, Jennifer G McIntosh, Ingrid M Winship, Mark Clendenning, Shakira Milton, Jasmeen Oberoi, James G Dowty, Daniel D Buchanan, Mark A Jenkins, Jon D Emery

Public Health Genomics | KARGER | Published : 2020

Abstract

INTRODUCTION: Genomic tests can predict risk and tailor screening recommendations for colorectal cancer (CRC). Primary care could be suitable for their widespread implementation. OBJECTIVE: We aimed to assess the feasibility and acceptability of administering a CRC genomic test in primary care. METHODS: Participants aged 45-74 years recruited from 4 Australian general practices were offered a genomic CRC risk test. Participants received brief verbal information about the test comprising 45 CRC-associated single-nucleotide polymorphisms, before choosing whether to undertake the test. Personalized risks were given to testers. Uptake and knowledge of the genomic test, cancer-specific anxiety (C..

View full abstract

Grants

Awarded by Cancer Research UK


Funding Acknowledgements

This study was supported by the Primary Care Collaborative Cancer Clinical Trials Group (PC4). This research is linked to the CanTest Collaborative, which is funded by Cancer Research UK (C8640/A23385), of which J.D.E. is the associate director. S.S. is supported by an Australian Government Research Training Program (RTP) Scholarship. J.D.E. is supported by an NHMRC Practitioner Fellowship. M.A.J. is an NHMRC Senior Research Fellow. The authors' funders played no part in the design, analysis, or drafting of this manuscript.