Using Brain Imaging to Improve Spatial Targeting of Transcranial Magnetic Stimulation for Depression.
Robin FH Cash, Anne Weigand, Andrew Zalesky, Shan H Siddiqi, Jonathan Downar, Paul B Fitzgerald, Michael D Fox
Biol Psychiatry | Elsevier BV | Published : 2020
Transcranial magnetic stimulation (TMS) is an effective treatment for depression but is limited in that the optimal therapeutic target remains unknown. Early TMS trials lacked a focal target and thus positioned the TMS coil over the prefrontal cortex using scalp measurements. Over time, it became clear that this method leads to variation in the stimulation site and that this could contribute to heterogeneity in antidepressant response. Newer methods allow for precise positioning of the TMS coil over a specific brain location, but leveraging these precise methods requires a more precise therapeutic target. We review how neuroimaging is being used to identify a more focal therapeutic target fo..View full abstract