Journal article

Decreased bioefficacy of long-lasting insecticidal nets and the resurgence of malaria in Papua New Guinea

Rebecca Vinit, Lincoln Timinao, Nakei Bubun, Michelle Katusele, Leanne J Robinson, Peter Kaman, Muker Sakur, Leo Makita, Lisa Reimer, Louis Schofield, William Pomat, Ivo Mueller, Moses Laman, Tim Freeman, Stephan Karl

Nature Communications | NATURE PUBLISHING GROUP | Published : 2020

Abstract

Papua New Guinea (PNG) has the highest malaria transmission outside of Africa. Long-lasting insecticidal nets (LLINs) are believed to have helped to reduce average malaria prevalence in PNG from 16% in 2008 to 1% in 2014. Since 2015 malaria in PNG has resurged significantly. Here, we present observations documenting decreased bioefficacy of unused LLINs with manufacturing dates between 2013 and 2019 collected from villages and LLIN distributors in PNG. Specifically, we show that of n = 167 tested LLINs manufactured after 2013, only 17% are fulfilling the required World Health Organisation bioefficacy standards of ≥ 80% 24 h mortality or ≥ 95% 60 min knockdown in bioassays with pyrethroid sus..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC) Career Development Fellowship


Funding Acknowledgements

We would like to thank all PNG communities who provided LLINs for testing and the RAM teams for collecting the LLINs. This study was funded in part by the Global Fund to Fight Aids, Tuberculosis and Malaria. L.T. is supported by a PhD Scholarship from James Cook University. M.K. is the recipient of a Wellcome Trust International Masters Fellowship. S.K. (GNT1141441) and L.J.R. (GNT1161627) are recipients of an Australian National Health and Medical Research Council (NHMRC) Career Development Fellowship.