Journal article

Doxycycline and Sitafloxacin Combination Therapy for Treating Highly Resistant Mycoplasma genitalium

Duygu Durukan, Michelle Doyle, Gerald Murray, Kaveesha Bodiyabadu, Lenka Vodstrcil, Eric PF Chow, Jorgen S Jensen, Christopher K Fairley, Ivette Aguirre, Catriona S Bradshaw

EMERGING INFECTIOUS DISEASES | CENTERS DISEASE CONTROL & PREVENTION | Published : 2020

Abstract

Antimicrobial-resistant Mycoplasma genitalium is becoming increasingly common and creating major treatment challenges. We present early data on combination therapy with doxycycline and sitafloxacin to treat highly resistant M. genitalium. We found the regimen was well tolerated and cured 11/12 infections that had failed prior regimens with moxifloxacin and pristinamycin.

Grants

Awarded by National Health and Medical Research Council Early Career Fellowship


Funding Acknowledgements

This work was supported by Monash University Central Clinical School departmental scholarship to D.D. and the National Health and Medical Research Council Early Career Fellowship to E.P.F.C. (no. 1091226).