Journal article

T helper 17 cell-related cytokines in serum and saliva during management of periodontitis

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Ivan B Darby, Neil M O'Brien-Simpson, Eric C Reynolds

Cytokine | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2020

Abstract

AIM: T helper (Th)17 cells are implicated in the pathogenesis of periodontitis. This study investigated the effect of periodontal management on fifteen Th17-related cytokines in serum and saliva in periodontitis patients. MATERIALS AND METHODS: Periodontal parameters, serum and saliva were collected from 40 healthy controls and 54 periodontitis subjects before treatment, and 3-, 6- and 12-months post-treatment. Cytokine concentrations of IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN-γ, sCD40L and TNF-α were determined by Luminex assay. RESULTS: IL-1β, IL-6, sCD40L and TNF-α in serum, and IL-1β, IL-6, IL-25 and IL-31 in saliva were significantly highe..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Australian Periodontology Research Foundation


Funding Acknowledgements

This study was supported by grants from the Australian National Health and Medical Research Council (1029878) and the Australian Periodontology Research Foundation (APRF2016). NM was supported by the Oral Health Cooperative Research Centre Top-up Scholarship.