Journal article

T helper 17 cell-related cytokines in serum and saliva during management of periodontitis

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Ivan B Darby, Neil M O'Brien-Simpson, Eric C Reynolds

CYTOKINE | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2020

Abstract

AIM: T helper (Th)17 cells are implicated in the pathogenesis of periodontitis. This study investigated the effect of periodontal management on fifteen Th17-related cytokines in serum and saliva in periodontitis patients. MATERIALS AND METHODS: Periodontal parameters, serum and saliva were collected from 40 healthy controls and 54 periodontitis subjects before treatment, and 3-, 6- and 12-months post-treatment. Cytokine concentrations of IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN-γ, sCD40L and TNF-α were determined by Luminex assay. RESULTS: IL-1β, IL-6, sCD40L and TNF-α in serum, and IL-1β, IL-6, IL-25 and IL-31 in saliva were significantly highe..

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