Germline mutations in new susceptibility genes for non-high-grade serous ovarian cancer.
Marina Pavanello, Ed Dicks, Honglin Song, Amir Ariff, Adelyn Bolithon, Maria P Intermaggio, Mark Pinese, Kirsten Moysich, Kunle O Odunsi, Ellen Goode, David D Bowtell, Peter Fasching, Jennifer A Doherty, Francesmary Modugno, Susanne K Kjaer, Penelope M Webb, Anna Wu, Anna deFazio, Paul James, Deepak Subramanian Show all
CLINICAL CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2020
Abstract Improving risk prediction and prevention strategies through identifying new susceptibility genes for non-high-grade serous ovarian cancer (non-HGS) would represent an important advance in reducing incidence and mortality. Epithelial ovarian cancer (EOC) has five main histotypes that have distinct pathologies, molecular changes, clinical characteristics, and tissues of origin. They are classified as high-grade serous (HGS), low-grade serous (LGS), clear-cell (CCC), endometrioid (END), and mucinous (MUC). A family history of breast or ovarian cancer is the strongest single risk factor for EOC. Germline mutations in the high-penetrance susceptibility genes BRCA1 and BRCA..View full abstract