Recent insights into the biology of Barrett's esophagus
Henry Badgery, Lynn Chong, Elhadi Iich, Qin Huang, Smitha Rose Georgy, David H Wang, Matthew Read
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | WILEY | Published : 2020
Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), an aggressive cancer with a poor prognosis. Our understanding of the pathogenesis and Barrett's metaplasia is incomplete, and this has limited the development of new therapeutic targets and agents, risk stratification ability, and management strategies. This review outlines current insights into the biology of BE and addresses controversies surrounding cell of origin, cellular reprogramming theories, updates on esophageal epithelial barrier function, and the significance of goblet cell metaplasia and its association with malignant change. Further research into the basic biology of BE is vital as it will ..View full abstract
M.R. is the recipient of a Senior Lecturer Fellowship from the Royal Australasian College of Surgeons.