Journal article

The role of hepatitis B surface antibodies in HBV infection, disease and clearance

Nadia Warner, Stephen Locarnini, Hui Xu



The clinical sequelae associated with chronic HBV infection is generally regarded as a consequence of an inadequate and inappropriate immune response to active viral replication, predominantly at the T-cell level. However, recent studies on hepatitis B surface antigen (HBsAg)-specific B cells and hepatitis B surface antibody (anti-HB) responses have identified their previously unrecognized role in the pathogenesis of chronic hepatitis B (CHB). These studies have also uncovered novel therapeutic approaches to more effectively target HBsAg loss and seroconversion, an important end point and regarded as a functional cure. Anti-HBs IgG has also been shown to have multiple direct acting antiviral..

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Awarded by NHMRC Grant

Funding Acknowledgements

This work was partly supported by NHMRC Grant, project number APP1127538. S Locarnini receives consulting fees from Gilead Sciences, Biotron and Clear-B Pty Ltd. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.