Journal article

Characterizing White Matter Tract Organization in Polymicrogyria and Lissencephaly: A Multifiber Diffusion MRI Modeling and Tractography Study

F Arrigoni, D Peruzzo, S Mandelstam, G Amorosino, D Redaelli, R Romaniello, R Leventer, R Borgatti, M Seal, JY-M Yang

American Journal of Neuroradiology | AMER SOC NEURORADIOLOGY | Published : 2020


BACKGROUND AND PURPOSE: Polymicrogyria and lissencephaly may be associated with abnormal organization of the undelying white matter tracts that have been rarely investigated so far. Our aim was to characterize white matter tract organization in polymicrogyria and lissencephaly using constrained spherical deconvolution, a multifiber diffusion MR imaging modeling technique for white matter tractography reconstruction. MATERIALS AND METHODS: We retrospectively reviewed 50 patients (mean age, 8.3 ± 5.4 years; range, 1.4-21.2 years; 27 males) with different polymicrogyria (n = 42) and lissencephaly (n = 8) subtypes. The fiber direction-encoded color maps and 6 different white matter tracts recons..

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Awarded by Royal Columbian Hospital Foundation

Awarded by National Institute of Neurologic Disorders and Stroke

Funding Acknowledgements

This study was funded by the Italian Ministry of Health (Ricerca Corrente 2018 and 2019 to Drs Arrigoni and Borgatti). Dr Arrigoni was also funded by the Australian Government through the Endeavor Research Fellowship program 2018 and by "Fondazione Banca del Monte di Lombardia." Dr Yang was funded by the Royal Columbian Hospital Foundation (RCH-1000). The research was supported by the Royal Children's Hospital Foundation, Murdoch Children's Research Institute, The University of Melbourne Department of Pediatrics, and the Victorian Government's Operational Infrastructure Support Program. Data used in the preparation of this article were obtained from the Pediatric MRI Data Repository created by the National Institutes of Health MRI Study of Normal Brain Development. This is a multisite, longitudinal study of typically developing children, from ages neonate through young adulthood, conducted by the Brain Development Cooperative Group and supported by the National Institute of Child Health and Human Development, the National Institute on Drug Abuse, the National Institute of Mental Health, and the National Institute of Neurologic Disorders and Stroke (contract Nos. N01HD02-3343, N01-MH9-0002, and N01-NS-9-2314, -2315, -2316, -2317, -2319 and -2320).