Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework

Alan A Cohen; Brian K Kennedy; Ulrich Anglas; Anne M Bronikowski; Joris Deelen; Frederik Dufour; Gerardo Ferbeyre; Luigi Ferrucci; Claudio Franceschi; Daniela Frasca; Bertrand Friguet; Pierrette Gaudreau; Vadim N Gladyshev; Efstathios S Gonos; Vera Gorbunova; Philipp Gut; Mikhail Ivanchenko; Veronique Legault; Jean-Francois Lemaitre; Thomas Liontis; Guang-Hui Liu; Mingxin Liu; Andrea B Maier; Otavio T Nobrega; Marcel GM Olde Rikkert; Graham Pawelec; Sylvie Rheault; Alistair M Senior; Andreas Simm; Sonja Soo; Annika Traa; Svetlana Ukraintseva; Quentin Vanhaelen; Jeremy M Van Raamsdonk; Jacek M Witkowski; Anatoliy Yashin; Robert Ziman; Tamas Fulop

Journal article

Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework

Alan A Cohen, Brian K Kennedy, Ulrich Anglas, Anne M Bronikowski, Joris Deelen, Frederik Dufour, Gerardo Ferbeyre, Luigi Ferrucci, Claudio Franceschi, Daniela Frasca, Bertrand Friguet, Pierrette Gaudreau, Vadim N Gladyshev, Efstathios S Gonos, Vera Gorbunova, Philipp Gut, Mikhail Ivanchenko, Veronique Legault, Jean-Francois Lemaitre, Thomas Liontis Show all

Mechanisms of Ageing and Development | ELSEVIER IRELAND LTD | Published : 2020

DOI: 10.1016/j.mad.2020.111316

Abstract

At a recent symposium on aging biology, a debate was held as to whether or not we know what biological aging is. Most of the participants were struck not only by the lack of consensus on this core question, but also on many basic tenets of the field. Accordingly, we undertook a systematic survey of our 71 participants on key questions that were raised during the debate and symposium, eliciting 37 responses. The results confirmed the impression from the symposium: there is marked disagreement on the most fundamental questions in the field, and little consensus on anything other than the heterogeneous nature of aging processes. Areas of major disagreement included what participants viewed as t..

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University of Melbourne Researchers

Andrea Maier Author Medicine - Royal Melbourne Hospital

Grants

Awarded by CIHR

Awarded by DECRA fellowship from the Australian Research Council

Awarded by Brazilian Council for Scientific and Technological Development (CNPq)

Awarded by NIA/NIH

Awarded by Ministry of Education and Science of the Russian Federation

Funding Acknowledgements

A.A.C. is supported by a Canadian Institutes of Health Research (CIHR) New Investigator Salary Award and is a member of the< GS2> Fonds de recherche du Quebec -Sante (FRQ-S)< GS2> funded Centre de recherche du CHUS and Centre de recherche sur le vieillissement, as well as by a CIHR project grant (153011). A.M.S. is supported by a DECRA fellowship from the Australian Research Council (DE180101520). VG and VNG are supported by grants from US National Institutes of Health. D.F. is supported by NIHAG059719 and AG023717. OTN is supported by the Brazilian Council for Scientific and Technological Development (CNPq) with a research productivity grant (3035402019-2). S.U. is supported by the NIA/NIH grantsR01AG062623 and R01AG070487. A.I.Y is supported by the NIA/NIH grants RF1AG046860, R01AG070487, and U19AG063893. CF and MI are supported by a grant of the Ministry of Education and Science of the Russian Federation Agreement No. 074-02-2018-330.