Catastrophic consequences: can the feline parasiteToxoplasma gondiiprompt the purrfect neuroinflammatory storm following traumatic brain injury?
Tamara L Baker, Mujun Sun, Bridgette D Semple, Shiraz Tyebji, Christopher J Tonkin, Richelle Mychasiuk, Sandy R Shultz
JOURNAL OF NEUROINFLAMMATION | BMC | Published : 2020
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide; however, treatment development is hindered by the heterogenous nature of TBI presentation and pathophysiology. In particular, the degree of neuroinflammation after TBI varies between individuals and may be modified by other factors such as infection. Toxoplasma gondii, a parasite that infects approximately one-third of the world's population, has a tropism for brain tissue and can persist as a life-long infection. Importantly, there is notable overlap in the pathophysiology between TBI and T. gondii infection, including neuroinflammation. This paper will review current understandings of the clinic..View full abstract
TLB is supported by an Australian Government Research Training Program (RTP) Scholarship.