Journal article

Correlation of positron emission tomography ventilation-perfusion matching with CT densitometry in severe emphysema

Asha Bonney, Carrie-Anne Wagner, Shankar Siva, Jason Callahan, Pierre-Yves Le Roux, Diane M Pascoe, Louis Irving, Michael S Hofman, Daniel P Steinfort



BACKGROUND: Emphysema severity is frequently measured on CT via densitometry. Correlation with scintigraphic and spirometric functional measures of ventilation or perfusion varies widely, and no prior study has evaluated correlation between densitometry and lobar ventilation/perfusion in patients with severe emphysema. The aim of this study was to evaluate the utility and findings of gallium-68 (68Ga) ventilation/perfusion positron emission tomography-CT (68Ga-VQ/PET-CT) in severe emphysema assessment. METHODS: Fourteen consecutive patients undergoing evaluation for bronchoscopic lung volume reduction between March 2015 and March 2018 underwent 68Ga-VQ/PET-CT assessment for lobar functional ..

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Awarded by Priority-drive Collaborative Cancer Research Scheme 2013 grant

Funding Acknowledgements

This trial was indirectly supported by a Priority-drive Collaborative Cancer Research Scheme 2013 grant (APP 1060919). We thank the contribution of Mr Peter Eu, for provision of radiopharmaceuticals used in this research. MSH is supported by a Clinical Fellowship Award from the Peter MacCallum Foundation.