Decidual mesenchymal stem/stromal cell-derived extracellular vesicles ameliorate endothelial cell proliferation, inflammation, and oxidative stress in a cell culture model of preeclampsia
Shixuan Zheng, Aiwu Shi, Sophia Hill, Claire Grant, Maria I Kokkinos, Padma Murthi, Harry M Georgiou, Shaun P Brennecke, Bill Kalionis
Pregnancy Hypertension | Elsevier | Published : 2020
Oxidative stress and endothelial dysfunction contribute substantially to the pathogenesis of preeclampsia (PE). Decidual mesenchymal stem/stromal cells (DMSC), reportedly reduce endothelial cell dysfunction and alleviate PE-like symptoms in a murine model. However, as a therapeutic strategy, the use of whole DMSC presents significant technical limitations, which may be overcome by employing DMSC-secreted extracellular vesicles (DMSC_EV). DMSC_EV restoration of endothelial dysfunction through a paracrine effect may alleviate the clinical features of PE. OBJECTIVE: To determine whether DMSC-secreted, extracellular vesicles (DMSC_EV) restore endothelial cell function and reduce oxidative st..View full abstract
The Trevor Basil Kilvington Bequest, Grant-in-Aid for Preeclampsia Research, The University of Melbourne supported the work, in addition to internal department funds.