Journal article

Innate immune responses to malaria-infected erythrocytes in pregnant women: Effects of gravidity, malaria infection, and geographic location

Marzieh Jabbarzare, Madi Njie, Anthony Jaworowski, Alexandra J Umbers, Maria Ome-Kaius, Wina Hasang, Louise M Randall, Bill Kalionis, Stephen J Rogerson



BACKGROUND: Malaria in pregnancy causes maternal, fetal and neonatal morbidity and mortality, and maternal innate immune responses are implicated in pathogenesis of these complications. The effects of malaria exposure and obstetric and demographic factors on the early maternal immune response are poorly understood. METHODS: Peripheral blood mononuclear cell responses to Plasmodium falciparum-infected erythrocytes and phytohemagglutinin were compared between pregnant women from Papua New Guinea (malaria-exposed) with and without current malaria infection and from Australia (unexposed). Elicited levels of inflammatory cytokines at 48 h and 24 h (interferon γ, IFN-γ only) and the cellular sourc..

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Awarded by National Health and Medical Research Council of Australia

Awarded by Bill and Melinda Gates Foundation

Awarded by Pregvax Consortium through European Union

Funding Acknowledgements

This work was supported by funds from a Program Grant from the National Health and Medical Research Council of Australia, APP1092789. Sample collection in Papua New Guinea was supported by the Malaria in Pregnancy Consortium, which is funded through a grant (46099) from the Bill and Melinda Gates Foundation to the Liverpool School of Tropical Medicine; the Pregvax Consortium, through a grant from the European Union's Seventh Framework Programme FP7-2007-HEALTH (PREGVAX 201588). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.