Developmental origins of cardiometabolic health outcomes in twins: A systematic review and meta-analysis
Deborah N Ashtree, Amelia J McGuinness, Michelle Plummer, Cong Sun, Jeffrey M Craig, Katrina J Scurrah
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | ELSEVIER SCI LTD | Published : 2020
BACKGROUND AND AIMS: Studies of twins can reduce confounding and provide additional evidence about the causes of disease, due to within-pair matching for measured and unmeasured factors. Although findings from twin studies are typically applicable to the general population, few studies have taken full advantage of the twin design to explore the developmental origins of cardiometabolic health outcomes. We aimed to systematically review the evidence from twin studies and generate pooled estimates for the effects of early-life risk factors on later-life cardiometabolic health. METHODS AND RESULTS: An initial search was conducted in March 2018, with 55 studies of twins included in the review. Ri..View full abstract
This work was supported by the Australian Government Research Training Program [administered by the University of Melbourne to D.N.A. and administered by the University of Adelaide to M.P.]; Twins Research Australia, which receives support from the National Health and Medical Research Council through a Centre of Research Excellence Grant, administered by the University of Melbourne [to K.J.S.]; ANZ trustees, Medical Research and Technology in Victoria [to C.S.] and an Australian Rotary Health/Ten Islands Tassie Tag Along Tour [Funding Partner, to A.J.M.].