Journal article

Developmental origins of cardiometabolic health outcomes in twins: A systematic review and meta-analysis

Deborah N Ashtree, Amelia J McGuinness, Michelle Plummer, Cong Sun, Jeffrey M Craig, Katrina J Scurrah

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | ELSEVIER SCI LTD | Published : 2020

Abstract

BACKGROUND AND AIMS: Studies of twins can reduce confounding and provide additional evidence about the causes of disease, due to within-pair matching for measured and unmeasured factors. Although findings from twin studies are typically applicable to the general population, few studies have taken full advantage of the twin design to explore the developmental origins of cardiometabolic health outcomes. We aimed to systematically review the evidence from twin studies and generate pooled estimates for the effects of early-life risk factors on later-life cardiometabolic health. METHODS AND RESULTS: An initial search was conducted in March 2018, with 55 studies of twins included in the review. Ri..

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