Journal article

Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer

Vito Carlo Alberto Caponio, Giuseppe Troiano, Iolanda Adipietro, Khrystyna Zhurakivska, Claudia Arena, Domenica Mangieri, Marco Mascitti, Nicola Cirillo, Lorenzo Lo Muzio

BRITISH JOURNAL OF CANCER | SPRINGERNATURE | Published : 2020

Abstract

BACKGROUND: Mutations of the tumour-suppressor gene TP53 are the most frequent somatic genomic alterations in head and neck squamous cell carcinoma (HNSCC). However, it is not yet clear whether specific TP53 mutations bear distinct clinical and pathophysiological significance in different HNSCC subgroups. METHODS: A systematic bioinformatics appraisal of TP53 mutations was performed on 415 HNSCC cases available on The Cancer Genome Atlas (TCGA). The following features were analysed and correlated with known clinicopathological variables: mutational profile of TP53, location (within secondary structure and predicted domains of p53 protein) and well-known hotspot mutations. Interactome-genome-..

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University of Melbourne Researchers