Journal article

Validation of online functiona measures in cognitively impaired older adults

Rachel L Nosheny, Monica R Camacho, Chengshi Jin, John Neuhaus, Diana Truran, Derek Flenniken, Miriam Ashford, Maria C Carrillo, Keith N Fargo, James Hendrix, Lucy Hanna, Gil Rabinovici, Paul Maruff, R Scott Mackin, Michael W Weiner

Alzheimer's & Dementia | WILEY | Published : 2020


INTRODUCTION: Assessment of functional status is associated with risk of cognitive decline and diagnosis of dementia, and can be assessed by participants and study partners (SPs). METHODS: In 770 older adults enrolled in the Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) study and the online Brain Health Registry (BHR), we estimated associations between online assessments and clinical variables related to Alzheimer's disease (AD) risk. RESULTS: Worse online learning scores and SP-reported functional decline were associated with higher probability of AD dementia diagnosis and poor in-clinic cognitive assessment, and with higher odds of amyloid beta (Aβ) positivity when combined with p..

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University of Melbourne Researchers


Awarded by National Institutes of Health

Awarded by Alzheimer's Association

Awarded by Larry L. Hillblom Foundation

Funding Acknowledgements

National Institutes of Health, Grant/Award Number: K01AG055692; Alzheimer's Association, Grant/Award Number: BHR-16-459161; Larry L. Hillblom Foundation, Grant/Award Number: 2015-A-011-NET; CaliforniaDepartment of Public Health, Grant/Award Number: 16-10323