Journal article

Safety of meningococcal B vaccine (4CMenB) in adolescents in Australia

HS Marshall, AP Koehler, B Wang, M A'Houre, M Gold, H Quinn, N Crawford, N Pratt, TR Sullivan, K Macartney

VACCINE | ELSEVIER SCI LTD | Published : 2020

Abstract

BACKGROUND: Four-component meningococcal B (4CMenB) vaccine is licensed in many countries but has had limited use in adolescents despite this age group being at increased risk of meningococcal disease. OBJECTIVES: To assess the safety profile of two doses of 4CMenB in adolescents. METHODS: Cluster randomised controlled trial of senior school students in South Australia (SA) with participating schools randomised to intervention (4CMenB) or control. Vaccine safety was monitored using the South Australian Vaccine Safety Surveillance System (SAVSS), a spontaneous reporting system for adverse events following immunisation (AEFI) with enhanced follow-up of AEFI. RESULTS: 58,637 doses of 4CMenB vac..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

GlaxoSmithKline financially supported the carriage study but were not involved in the safety component of the study. HM receives research support from the National Health and Medical Research Council Practitioner Fellowship APP1155066.